Diabetes is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. If left untreated, diabetes can cause many complications. Acute complications include diabetic ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include cardiovascular disease, stroke, chronic kidney failure, foot ulcers, and damage to the eyes. Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced. There are three main types of diabetes mellitus:
Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin properly. As the disease progresses a lack of insulin may also develop. This form was previously referred to as "non insulin-dependent diabetes mellitus" (NIDDM) or "adult-onset diabetes". The primary cause is excessive body weight and not enough exercise.
Gestational diabetes, is the third main form and occurs when pregnant women without a previous history of diabetes develop a high blood sugar level.
As of 2014, an estimated 387 million people have diabetes worldwide, with type 2 diabetes making up about 90% of the cases. This represents 8.3% of the adult population, with equal rates in both women and men. From 2012 to 2014, diabetes is estimated to have resulted in 1.5 to 4.9 million deaths each year.
Diabetes at least doubles a person's risk of death. The number of people with diabetes is expected to rise to 592 million by 2035. The global economic cost of diabetes in 2014 was estimated to be $612 billion USD. In the United States, diabetes cost $245 billion in 2012. Read more ...
The Scary Way Diabetes Affects Thinking Skills And Brain Function Huffington Post - July 11, 2015
After two years, the people with diabetes showed greater declines in gray matter as well as impairments in their ability to regulate blood flow in the brain than the people without. Blood flow regulation decreased by an average of 65 percent in the participants with diabetes. Among participants with diabetes, scores on thinking and memory tests decreased by an average of 12 percent, from 46 to 41 points, while test scores of the participants without diabetes stayed the same at 55 percent. Higher levels of inflammation were correlated with greater difficulties with blood flow regulation. Those with the highest levels of blood flow regulation impairment at the outset of the study had more difficulties performing daily activities (such as cooking and bathing) after two years.
One injection stops diabetes in its tracks: Treatment reverses symptoms of type 2 diabetes in mice without side effects Science Daily - July 17, 2014
In mice with diet-induced diabetes -- the equivalent of type 2 diabetes in humans -- a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. The discovery could lead to a new generation of safer, more effective diabetes drugs. The team found that sustained treatment with the protein doesn't merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn't result in side effects common to most current diabetes treatments.
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